Download PDF
Synlett 1992; 1992(5): 431-434
DOI: 10.1055/s-1992-21371
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Zincke's Reaction with Chiral Primary Amines: A Practical Entry to Pyridinium Salts of Interest in Asymmetric Synthesis

Yves Genisson* , Christian Marazano, Maryam Mehmandoust, Dino Gnecco, Bhupesh C. Das
  • *Institut de Chimie des Substances Naturelles, CNRS, F-91128 Gif-sur-Yvette Cedex, France
Further Information

Publication History

Publication Date:
08 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

The scope of Zincke's synthesis of pyridinium salts using various chiral primary amines and mono- or dialkylpyridines substituted at positions 3, 4 or 5 has been investigated. Salts 6a-f, 9a-i, and 10b,e,h-j were obtained in excellent yields. The results support the accepted mechanism for Zincke's reaction and shows the influence of the solvent on the course of this reaction.

      >