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Synlett 1992; 1992(5): 399-401
DOI: 10.1055/s-1992-21358
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Total Synthesis of the Carboxylic Acid lonophore Antibiotic CP-61,405 (Routiennocin): Preparation of the Inherent Spiroketal Unit via a Reverse Coupling Process

David Díez-Martin* , Nikesh R. Kotecha, Steven V. Ley, J. Carlos Menéndez
  • *Department of Chemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, England
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08. März 2002 (online)

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π-Allyltricarbonyliron lactone complexes were used in the preparation of a 6-substituted 5-methyl-2-phenylsulphonylpyran 3 which when coupled with 6-iodo-1,3-O-isopropylidenehexane-1,3-diol (4) gave the inherent spiroketal fragment (2,8-disubstituted 1,7-dioxaspiro[5.5]undecane 2) of the ionophore antibiotic CP-61,405 (Routiennocin) 1.