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Synlett 1992; 1992(2): 137-138
DOI: 10.1055/s-1992-21293
DOI: 10.1055/s-1992-21293
letter
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data processing and storage.Chiral Allylsilanes Derived from Naturally Occurring α-Amino Acids
Further Information
Publication History
Publication Date:
08 March 2002 (online)

Natural occurring α-amino acids, N-butoxycarbonyl protected and converted into the corresponding aldehydes, were transformed into (Z)-alkenes 2-7 by Wittig olefination. Metalation with butyllithium-potassium tert-butoxide gave, after reaction with trimethylsilyl chloride, chiral allylsilanes [e.g., (Z)-(4S)-4-tert-butoxycarbonylamino-6-methyl-1-trimethylsilyl-2-heptene (10)]. The condensation of two of these with acetyl chloride-titanium(IV) chloride is also reported.