Synthesis of 2-Aryl-2-methylglycine Derivatives

C. Cativiela; M. P. López; J. A. Mayoral

doi:10.1055/s-1992-21285

Synlett 1992; 1992(2): 121-122
DOI: 10.1055/s-1992-21285

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Synthesis of 2-Aryl-2-methylglycine Derivatives

C. Cativiela^* , M. P. López, J. A. Mayoral

^*Departamento de Química Orgánica, Instituto de Ciencia de Materiales de Aragón, Universidad de Zaragoza, CSIC, E-50009-Zaragoza, Spain

Abstract

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N-Acetyl-α,-βdidehydroalanine methyl ester acts, in the presence of Lewis acids, as an electrophile in α-acetamidoalkylation reactions with furan and anisole. Boron trifluoride-diethyl ether complex was the most effective Lewis acid, and excellent yields of 2-methyl-2-(2-furyl)glycine and 2-methoxyphenyl-2-methylglycine were obtained.

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