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Synlett 1992; 1992(2): 121-122
DOI: 10.1055/s-1992-21285
DOI: 10.1055/s-1992-21285
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved.
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data processing and storage.Synthesis of 2-Aryl-2-methylglycine Derivatives
Further Information
Publication History
Publication Date:
08 March 2002 (online)

N-Acetyl-α,-βdidehydroalanine methyl ester acts, in the presence of Lewis acids, as an electrophile in α-acetamidoalkylation reactions with furan and anisole. Boron trifluoride-diethyl ether complex was the most effective Lewis acid, and excellent yields of 2-methyl-2-(2-furyl)glycine and 2-methoxyphenyl-2-methylglycine were obtained.