Download PDF
Synlett 1992; 1992(2): 117-118
DOI: 10.1055/s-1992-21283
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of (+)-Leukotriene B4 (LTB4) Methyl Ester and (-)-(5R)-LTB4 Methyl Ester via Pyrylium Methodology

Bennett C. Borer* , Richard J. K. Taylor
  • *School of Chemical Sciences, University of East Anglia, Norwich NR4 7TJ, England
Further Information

Publication History

Publication Date:
08 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

The title compounds (5S)- and (5R)-leukotriene B4 methyl esters (1) and (2), have been prepared from 3-nonenal by a short convergent synthetic route which utilises addition of 3-(tert-butyldimethylsiloxy)-1,5-undecadienyllithium (8) to pyrylium tetrafluoroborate for the construction of the crucial Z,E,E-triene unit.

      >