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Synlett 1992; 1992(1): 41-44
DOI: 10.1055/s-1992-21259
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A Convenient Method for the Preparation of Enantiomerically Pure 2-Substituted N-Tosylaziridines

Malcolm B. Berry* , Donald Craig
  • *Department of Chemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, England
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Publication Date:
18 September 2002 (online)

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A three-step procedure for the synthesis of enantiomerically pure 2-substituted N-tosylaziridines 4 is described. The method involves N-tosylation of (S)-2-amino acids 1, followed by reduction to give N-tosyl-2-amino alcohols 3 and O-tosylation with in situ aziridine ring closure.

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