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Synlett 1992; 1992(1): 39-40
DOI: 10.1055/s-1992-21258
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Selective Enzymatic Removal of Protecting Functions: Heptyl Esters as Carboxy Protecting Groups in Glycopeptide Synthesis

Peter Braun* , Herbert Waldmann, Horst Kunz
  • *Institut für Organische Chemie and Biochemie der Universität, Gerhard-Domagk-Straße 1, D-5300 Bonn 1, Germany
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Publication Date:
18 September 2002 (online)

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The selective C-terminal deprotection of acid- and base-labile multifunctional O-glycopeptide heptyl (Hep) esters is achieved under mild conditions (pH 7; 37 °C) by enzymatic hydrolysis with a lipase from Mucor javanicus.

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