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Synlett 1991; 1991(10): 753-754
DOI: 10.1055/s-1991-34774
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Enzymatic Synthesis of 2′,3′-Dideoxyguanosine

Vasu Nair* , Todd B. Sells
  • *Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
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Publikationsdatum:
13. März 2002 (online)

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2′,3′-Dideoxyguanosine (ddG) can be conveniently synthesized in very high yields by utilizing the hydrolase activity of the ubiquitous mammalian enzyme, adenosine deaminase (ADA). The immediate precursor in this synthesis is 2-amino-6-chloro-2′,3′-dideoxypurine nucleoside, which is readily prepared from guanosine.