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Synlett 1991; 1991(10): 693-694
DOI: 10.1055/s-1991-34758
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Ruthenium-Catalyzed Transformations of Amino Alcohols to Lactams

Takeshi Naota* , Shun-Ichi Murahashi
  • *Department of Chemistry, Faculty of Engineering Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560, Japan
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Publication Date:
13 March 2002 (online)

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1,4- and 1,5-Amino alcohols undergo oxidative condensation upon treatment with dihydridotetrakis(triphenylphosphine)ruthenium(II) catalyst in the presence of a hydrogen acceptor to give the corresponding lactams. The principle of the present reaction can be extended to amide formation from aromatic aldehydes and secondary amines.

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