Synthesis of 1-Aminocyclopropanol by Anodic Oxidation
13 March 2002 (online)
The decarboxylation of 2-(tert-butoxycarbonylamino)isobutyric acid (2) by anodic oxidation in methanol or ethanol gives the corresponding tert-butyl N-(1-alkoxy-1-methylethyl)carbamates 3. The decarboxylation of 1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid offers a new and efficient synthesis of tert-butyl N-(1-ethoxycyclopropyl)carbamate. Hydrolysis with acid yields the hydrochloride of 1-aminocyclopropanol, a potent enzyme inhibitor.