Regioselective Amidation of Aspartic and Glutamic Acid

Kee-In Lee; Jae Hak Kim; Kwang-Youn Ko; Wan-Joo Kim

doi:10.1055/s-1991-26610

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Synthesis 1991; 1991(11): 935-936
DOI: 10.1055/s-1991-26610

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Regioselective Amidation of Aspartic and Glutamic Acid

Kee-In Lee^* , Jae Hak Kim, Kwang-Youn Ko, Wan-Joo Kim

^*Korea Research Institute of Chemical Technology, Taejeon 305-606, South Korea

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Publikationsdatum:
29. April 2002 (online)

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The synthesis of N-protected aspartic 1-amide and glutamic 1-amide from aspartic and glutamic acids via regioselective amidation of intermediate 5-oxazolidinone derivatives with aqueous ammonia or amine is described.