Application of the Bifunctional Phosphonylating Agent Bis[6-(trifluoromethyl)benzotriazol-1-yl] Methylphosphonate Towards the Preparation of Isosteric D-myo-Inositol Phospholipid and Phosphate Analogues

C. E. Dreef; M. Douwes; C. J. J. Elie; G. A. van der Marel; J. H. van Boom

doi:10.1055/s-1991-26488

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Synthesis 1991; 1991(6): 443-447
DOI: 10.1055/s-1991-26488

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Application of the Bifunctional Phosphonylating Agent Bis[6-(trifluoromethyl)benzotriazol-1-yl] Methylphosphonate Towards the Preparation of Isosteric D-myo-Inositol Phospholipid and Phosphate Analogues

C. E. Dreef^* , M. Douwes, C. J. J. Elie, G. A. van der Marel, J. H. van Boom

^*Gorlaeus Laboratories, P.O. Box 9502, NL-2300 RA Leiden, The Netherlands

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Publikationsdatum:
29. April 2002 (online)

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The individual diastereoisomeric methylphosphonate analogues of phosphatidyl D-myo-inositol A (R _p and S _p) and D-myo -inositol 1-(sodium methylphosphonate) were prepared using the bifunctional phosphonylating agent bis[6-(trifluoromethyl)benzotriazol-1-yl] methylphosphonate.