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Synthesis 1991; 1991(5): 379-381
DOI: 10.1055/s-1991-26470
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A Convenient Synthesis of 5-Substituted 2-Pyrrolidinones via 2H-Pyran-3(6H)-ones

Minas P. Georgiadis* , Serkos A. Haroutounian, Costas D. Apostolopoulos
  • *Agricultural University of Athens, Chemistry Lab., Iera odos 75, Athens 11855, Greece
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Publikationsdatum:
29. April 2002 (online)

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Jones oxidation of 6-hydroxy-2H-pyran-3(6H)-ones, subsequent hydrogenation, oxime formation and catalytic hydrogenation constitute an efficient route for the synthesis of various 5-substituted 2-pyrrolidinone derivatives starting from aldehydes or ketones.