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Synlett 1991; 1991(11): 827-829
DOI: 10.1055/s-1991-20893
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Synthesis of Atropisomeric Biphenylbisphosphine, 6,2′-Bis(diphenylphosphino)-3-methoxy-2, 4-dimethyl-4′,6′-bis(trifluoromethyl)-1,1′-biphenyl (FUPMOP) and Its Use in Ruthenium(II) -Catalyzed Asymmetric Hydrogenation of a 3-Oxo Ester1

Masanao Murata* , Toshiaki Morimoto, Kazuo Achiwa
  • *School of Pharmaceutical Sciences, University of Shizuoka, 395 Yada, Shizuoka 422, Japan
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Publication Date:
07 March 2002 (online)

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New atropisomeric biphenylbisphosphines, 6,2′ -bis(diphenylphosphino)-3-methoxy-2, 4-dimethyl-4′,6′ -bis(trifluoromethyl)-1,1′-biphenyl (FUPMOP) and 2,2′-bis(diphenylphoshino)-4,6,4′,6′-tetrakis(trifluoromethyl)-1, 1′-biphenyl (BIFUP), have been prepared from 2-bromo-3, 5-bis(trifluoromethyl)nitrobenzene. The FUPMOP-ruthenium(II) complex proved to be an excellent catalyst for the asymmetric hydrogenation of methyl 3-oxobutanoate.