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Synlett 1991; 1991(8): 591-592
DOI: 10.1055/s-1991-20809
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Direct Transformation of Nitroalkanes to Alkanoic Acids Under Mild Conditions

Elizabeth A. Saville-Stones* , Stephen D. Lindell
  • *Schering Agrochemicals Limited, Chesterford Park Research Station, Saffron Walden, Essex CB10 1XL, England
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Publication History

Publication Date:
07 March 2002 (online)

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Basic phosphate buffered (pH=11) potassium permanganate rapidly converts primary nitroalkanes (7 examples) into alkanoic acids in high yield and under mild conditions. The procedure tolerates the presence of ester, amide, primary alcohol and tetrahydropyranyl ether groups in the starting nitroalkane.

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