Synlett 1991; 1991(6): 409-411
DOI: 10.1055/s-1991-20745
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5-Vinyl-4-pentynoic Acids Through the Palladium-Catalyzed Reaction of 4-Pentynoic Acid with Vinyl Triflates

Antonio Arcadi* , Sandro Cacchi, Monica Delmastro, Fabio Marinella
  • *Dipartimento di Chimica, Ingegneria Chimica e Materiali, Università degli Studi, V. Assergi 4, I-67100 L'Aquila, Italy
Further Information

Publication History

Publication Date:
07 March 2002 (online)

A variety of 5-vinyl-4-pentynoic acids (12 examples) have been prepared in good to high yield by reacting vinyl triflates (1-cycloalkenyl trifluoromethanesulfonates) and 4-pentynoic acid at room temperature in dimethyl sulfoxide in the presence of diethylamine or diisopropylamine and catalytic amounts of diacetatobis(triphenylphosphine)palladium [Pd(OAc)2(PPh3)2] and copper(I) iodide.

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