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Synlett 1991; 1991(2): 91-92
DOI: 10.1055/s-1991-20637
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Novel Entry to a 3,4-Disubstituted 2-Azetidinone Derivative via Palladium-Assisted Carbonylation of a 2-Substituted 3-Vinylaziridine

Glen W. Spears* , Koji Nakanishi, Yasufumi Ohfune
  • *Suntory Institute for Bioorganic Research, Shimamoto-cho, Osaka 618, Japan
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Publication Date:
07 March 2002 (online)

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Highly stereoselective conversion of 2-benzyloxymethyl-1-(tert-butoxycarbonyl)-3-vinylaziridine (3) via ring opening, carbonylation and ring closure into trans-4-benzyloxymethyl-1-(tert-butoxycarbonyl)-3-vinyl-2-azetidinone (4) was accomplished by the use of palladium(0)/carbon monoxide.