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Synlett 1990; 1990(12): 757-758
DOI: 10.1055/s-1990-21241
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The Use of Sacrificial Anodes for Diastereoselective Formation of Pinacols

Hans Günter Thomas* , Klaus Littmann
  • *Institut für Organische Chemie, RWTH Aachen, Professor-Pirlet-Strasse 1, D-5100 Aachen, Germany
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Publication Date:
08 March 2002 (online)

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The electrochemical reduction of alkanals 1 arenecarbaldehydes 2, and aryl methyl ketones 3 with sacrificial zinc or magnesium anodes in dimethylformamide was carried out on a preparative scale to yield 1,2-diols 4-6 in moderate to nearly quantitative yield, depending on the compound class. The 1,2-diaryl 1,2-diols were obtained in very high diastereomeric excesses and in quantities of 35 g per run.

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