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Synlett 1990; 1990(10): 609-610
DOI: 10.1055/s-1990-21183
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An Expedient Route to the Quinolone Antibacterial Intermediate, 2,4,5-Trifluorobenzoic Acid

Neil J. O'Reilly* , William S. Derwin, Lawrence B. Fertel, Henry C. Lin
  • *Occidental Chemical Corporation, Technology Center, 2801 Long Road, Grand Island, New York 14072, USA
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Publication Date:
08 March 2002 (online)

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A short and efficient synthesis of the important quinolone antibacterial intermediate, 2,4,5-trifluorobenzoic acid (1), is reported. 3,4, 6-Trichlorophthalic acid is protected as an N-methyl- or N-phenylphthalimide and then fluorinated. Acid hydrolysis then gives 3,4, 6-trifluorophthalic acid which is selectively decarboxylated to give 1 in high yield.

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