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Synlett 1990; 1990(10): 601-602
DOI: 10.1055/s-1990-21180
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Trimethyl 4-Lithioorthobutanoate: Preparation and Synthetic Applications

Bennett C. Borer* , Richard J. K. Taylor
  • *School of Chemical Sciences, University of East Anglia, Norwich NR4 7TJ, England
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Publication Date:
08 March 2002 (online)

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The title reagent, prepared by lithiation of trimethyl 4-bromoorthobutanoate, reacts with aldehydes and ketones in high yield giving 5-hydroxypentanoates after hydrolysis. Preliminary details of the scope and limitations of this procedure are described.

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