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Synlett 1990; 1990(8): 463-465
DOI: 10.1055/s-1990-21127
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An Improved Diastereoselective Synthesis of 1,3-Amino Alcohols by Reduction of 1,3-Amino Ketone Derivatives

José Barluenga* , Enrique Aguilar, Bernardo Olano, Santos Fustero
  • *Departamento de Química Organometálica, Facultad de Química, Universidad de Oviedo, E-33071 Oviedo, Spain
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Publication Date:
08 March 2002 (online)

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3-Aryl(cycloalkyl)-3-amino-2-methyl-1-phenyl-1-propanols 3 with three chiral centers are obtained in a stereoselective manner by a two-step reduction of 1,3-amino ketone derivatives 2, obtained from 4-amino-1-azabutadienes 1.