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Synlett 1990; 1990(6): 326-328
DOI: 10.1055/s-1990-21079
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Total Synthesis of Avermectin B1a: Synthesis of the C11-C25 Spiroacetal Fragment

David Díez-Martín* , Peter Grice, Hartmuth C. Kolb, Steven V. Ley, Andrew Madin
  • *Department of Chemistry, Imperial College of Science, Technology and Medicine, London, SW7 2AY, England
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Publication Date:
08 March 2002 (online)

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During the synthesis of avermectin B1a (1) the C11-C25 spiroacetal portion 2 has been prepared using a novel sequence of reactions involving π-allyltricarbonyliron lactone complexes 5 and 6 for the preparation of the cyclic ether sulphone, 8 which in turn was coupled and spirocyclised to give 2.