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Synlett 1990; 1990(5): 265-266
DOI: 10.1055/s-1990-21058
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Synthesis of Chiral Polyfunctional γ-Lactones via an Intramolecular 1,6 Michael-Type Addition

Mohammed Laabassi* , René Grée
  • *Groupe de Recherche de Physicochimie Structurale, CNRS URA D0704, Université de Rennes I, Avenue du Gal Leclerc, F-35042 Rennes-Beaulieu, France
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Publication Date:
08 March 2002 (online)

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A short and efficient synthesis of chiral and functionalized γ-lactones 5 and 6 is described. It takes advantage of the highly stereoselective 1,6 Michael-type addition of a malonate anion to an electrophilic diene.