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Synlett 1990; 1990(2): 109-110
DOI: 10.1055/s-1990-21004
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Synthesis of Chiral Triamine Ligands from Ephedrine and Pseudoephedrine

R. Karl Dieter* , Bharat Lagu, Janice W. Dieter, Niranjan Deo, William T. Pennington
  • *Hunter Chemistry Laboratory, Clemson University, Clemson SC 29634-1905, USA
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Publication Date:
08 March 2002 (online)

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Ephedrine (2) and pseudoephedrine (3) can be alkylated with α-chloro-N,N-dimethylacetamide and converted regio- and stereospecifically into 1,2-diphenyl-3,4,7-trimethyl-1,4,7-triazaoctanes 1 and 6 via a substitution reaction at the carbinol stereogenic center.