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Synthesis 1989; 1989(12): 953-955
DOI: 10.1055/s-1989-27443
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A Convenient Synthesis of 3-Alkyl-4-aminobutanoic Acids

Ryszard Andruszkiewicz* , Richard B. Silverman
  • *Department of Chemistry and Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL-60208-3113, USA
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Publication Date:
02 May 2002 (online)

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A series of 3-alkyl-4-aminobutanoic acids were prepared via the Michael addition of nitromethane to 2-alkenoic esters, followed by catalytic hydrogenation of the resultant 3-(nitromethyl)alkanoic esters using 10% palladium on carbon in acetic acid, and acid hydrolysis of the reduction products.

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