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Synthesis 1989; 1989(9): 709-710
DOI: 10.1055/s-1989-27369
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A Modified Synthesis of 4-Chromanones

Brian Cox* , Roger D. Waigh
  • *Department of Pharmacy, University of Manchester, Manchester, M13 9PL, England
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Publication Date:
17 September 2002 (online)

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Problems in the synthesis of 4-chromanones by condensation of 2-hydroxyacetophenones with formaldehyde can be avoided by the isolation of the Mannich base hydrochlorides and cyclization by titration with potassium hydroxide.

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