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Synthesis 1989; 1989(6): 454-455
DOI: 10.1055/s-1989-27287
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Cobalt-Mediated Synthesis of Propargyl Nitriles and α-Alkoxy Propargyl Nitriles

John G. Stuart* , Kenneth M. Nicholas
  • *Department of Chemistry, University of Oklahoma, Norman, OK 73019, USA
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Publikationsdatum:
17. September 2002 (online)

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Dicobalt hexacarbonyl complexes of propargyl acetates and acetylenic acetals couple efficiently with diethylaluminum cyanide to produce the corresponding complexed propargyl nitriles and cyanohydrin derivatives, respectively. A convenient procedure far preparing propargyl nitriles and α-alkoxy propargyl nitriles from propargyl alcohols and acetylenic acetals using this methodology is described.