Synthesis 1989; 1989(6): 453-454
DOI: 10.1055/s-1989-27286
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Improved and Extended One-Step Conversion of Primary Amines into Nitriles by Copper-Catalyzed Oxidation

Patrice Capdevielle* , André Lavigne, Michel Maumy
  • *Laboratoire de Recherches Organiques de l'ESPCI, associé au CNRS, 10 rue Vauquelin, F-75231 Paris Cedex 05, France
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Publication History

Publication Date:
17 September 2002 (online)

An improved and extended methodology for Kametani's oxidation of primary amines to nitriles by the [CU(I)Cl/O2/pyridine] system is reported. By this procedure aliphatic or aromatic nitriles are obtained in almost quantitative yields with very high purity.