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Synthesis 1988; 1988(9): 746-748
DOI: 10.1055/s-1988-27698
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Efficient Synthesis of 4-Acylisoxazole Derivatives from Triformylmethane

Richard O. Angus, Jr.* , Martin R. Bryce, M. Keshavarz-K., Fred Wudl
  • *Institute for Polymers and Organic Solids, Department of Physics, University of California, Santa Barbara, CA 93106, USA
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Publication Date:
18 September 2002 (online)

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We show that a number of 4-substituted isoxazoles (4-cyano, 4-ethoxy-carbonyl) can be prepared efficiently from either triformylmethane or its trisdimethylimino precursor. We also report the preparation of cyano(formyl)acetamidine, a compound containing three different functional groups attached to one carbon atom.

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