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Synthesis 1988; 1988(9): 735-739
DOI: 10.1055/s-1988-27693
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Ein neuartiger Zugang zu Heteroarylmethyl-, Heteroarylethylphosphonsäure-estern und deren freien Säuren

Erich Zbiral* , Martina Drescher
  • *Institut für Organische Chemie der Universität Wien, A-1090 Wien, Währinger Straße 38, Austria
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Publication Date:
18 September 2002 (online)

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A Novel Approach to Heteroarylmethyl- and Heteroarylethylphosphonates (Imidazolylmethyl)-, (thiazolylmethyl)-, and (5-oxo-5,6-dihydroimidazo[1,2-c] pyrimidinylmethyl)triphenylphosphonium bromides (2, 3, 4) react with diethyl phosphiteanion or with the carbanion of ethyl diethoxyphosphorylacetate to give the corresponding heteroarylmethyl- or heteroarylphosphonates 5, 6, 8, 10, 12, 13. The free phosphonic acids 7, 8, 11, 14 can be prepared by cleavage with bromotrimethylsilane.

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