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Synthesis 1988; 1988(7): 553-555
DOI: 10.1055/s-1988-27637
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Synthesis of N-(5-Aminopyrazol-3-yl)amino and N(5-Amino-1,2,4-triazol-3-yl)amino Acids

Masataka Yokoyama* , Katsushi Kumata, Hidehiko Noro, Akemi Kogo
  • *Department of Chemistry, Faculty of Science, Chiba University, Yayoicho, Chiba City 260, Japan
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Publication Date:
18 September 2002 (online)

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Some N-(5-aminopyrazol-3-yl) and N-(5-amino-1,2,4-triazol-3-yl) derivatives of amino acids or dipeptides are synthesized in good yields from the reaction of α-(aminocarbonyl)-α-cyanoketene dithioacetals with amino acid or dipeptide tert-butyl esters and cyclocondensation of the resultant α-(aminocarbonyl)-α-cyanoketene S,N-acetals [N-(2-aminocarbonyl-2-cyano-1-methylthioethenyl)amino acid derivatives] with hydrazine hydrate.

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