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Synthesis 1988; 1988(6): 469-470
DOI: 10.1055/s-1988-27608
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Preparative Flow Techniques; 1. Low-Temperature Organometallic Reactions: Synthesis of Ethyl 2,2-Difluoro-4-pentenoate

Michael Kolb* , Fritz Gerhart, Jean-Paul François
  • *Merrell Dow Research Institute, Strasbourg Center, F-67000 Strasbourg, France
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Publication Date:
20 August 2002 (online)

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A convenient preparation of the synthetically useful ethyl 2,2-difluoro-4-pentenoate using the low-temperature flow technique is described. The method is suitable for small-scale as well as for large-scale application.

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