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Synthesis 1988; 1988(5): 410-411
DOI: 10.1055/s-1988-27598
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Resolution of Racemic Amines with 2-Methyl-2-phenylbutanedioic Acid

Milind M. Gharpure* , A. S. Rao
  • *National Chemical Laboratory, Pune 411 008, India
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Publication Date:
20 August 2002 (online)

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Five racemic amines were resolved in high chemical and optical yields using (S)-(+)-2-methyl-2-phenylbutanedioic acid as resolving reagent. The reagent can be recovered quantitatively and without any change in its optical purity. (R)-(-)-2-Methyl-2-phenylbutanedioic acid was also obtained.

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