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Synthesis 1988; 1988(5): 394-395
DOI: 10.1055/s-1988-27588
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A Convenient Synthesis of Aldehydes by Rearrangement of Cyclic Epoxides with Lithium Bromide on Alumina

Hisashi Suga* , Hajimu Miyake
  • *Minase Research Institute, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618, Japan
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Publication Date:
20 August 2002 (online)

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Epoxides can be converted effectively to aldehydes by rearrangement with lithium bromide supported on alumina. In the case of the alicyclic epoxides, ring contracted cycloalkanecarbaldehydes can be formed. The conversion is achieved by gas-phase reaction or in toluene as solvent.