Synthesis 1988; 1988(4): 336-337
DOI: 10.1055/s-1988-27565
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A Convenient, One-Pot-Synthesis of 12-Oxo-6,12-dihydroquinazolino [2,3-c][1,4]benzoxazines and -benzothiazines

C. V. Reddy Sastry* , K. Srinivasa Rao, V. S. H. Krishnan, K. Rastogi, M. L. Jain
  • *Chemistry Division, IDPL Research Centre, Indian Drugs & Pharmaceuticals Limited, Hyderabad 500 037, India
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Publication History

Publication Date:
20 August 2002 (online)

12-Oxo-6,12-dihydroquinazolino [2,3-c][1,4]-benzoxazines 3a-e and -benzothiazines 3f-i are easily prepared in very good yields in a onestep process by reacting the appropriate 3-oxo-3,4-dihydro-2H-1,4-benzoxazines and -benzthiazines 1 with phosphoryl chloride in dichloroethane followed by in situ cyclocondensation of the resulting imidoyl chlorides with anthranilic acid (2).