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A Simple, One-Pot Synthesis of 1-Alkoxy-1-alkynes and 1-Alkoxy-1-alkyn-3-ols
20 August 2002 (online)
The title compounds are prepared by a high yield, one-pot reaction using readily available chloroacetaldehyde dialkyl acetals as starting materials. The reaction is initiated by sodium amide and the intermediate acetylide anion thus produced, reacts readily with a variety of electrophiles such as alkyl halides, carbonyl compounds or water to produce the desired products.