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Synthesis 1988; 1988(3): 257-259
DOI: 10.1055/s-1988-27537
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Facile Synthesis of 4-Hydroxycoumarins by Sulfur-Assisted Carbonylation of 2′-Hydroxyacetophenones with Carbon Monoxide

Takumi Mizuno* , Ikuzo Nishiguchi, Tsuneaki Hirashima, Akiya Ogawa, Nobuaki Kambe, Noboru Sonoda
  • *Osaka Municipal Technical Research Institute, 1-6-50, Morinomiya, Jyoto-ku, Osaka 536, Japan
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Publication Date:
20 August 2002 (online)

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4-Hydroxycoumarins (4-hydroxy-2-oxo-2H-1-benzopyrans) were synthesized in good to excellent yields by C-carbonylation of 2′-hydroxyacetophenones with carbon monoxide in the presence of sulfur and bases. This is the first example of sulfur-assisted C-Carbonylation with carbon monoxide.

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