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Synthesis 1988; 1988(3): 231-233
DOI: 10.1055/s-1988-27524
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Utilization of Basic Alumina in a One-Pot Synthesis of 1,4-Diketones, 1,4,7-Triketones, and Dihydrojasmone by Conjugate Addition of Nitroalkanes to Enones

Roberto Ballini* , Marino Petrini, Enrico Marcantoni, Goffredo Rosini
  • *Dipartimento di Scienze Chimiche, Università, Via S. Agostino 1, I-62032 Camerino, Italy
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Publication Date:
20 August 2002 (online)

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The one-pot synthesis of functionalized 1,4-diketones was achieved in good yields by conjugate addition of primary nitroalkanes to α,β-unsaturated carbonyl compounds on basic alumina without solvent, followed by in situ oxidation with 30% aqueous hydrogen peroxide in methanol. The one-pot syntheses of 1,4,7-triketones and dihydrojasmone are also reported.