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Synthesis 1988; 1988(2): 140-142
DOI: 10.1055/s-1988-27493
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Horner Synthesis of Didehydroamino Acid Derivatives in a Liquid-Liquid Two-Phase System

Pier Giuseppe Ciattini* , Enrico Morera, Giorgio Ortar
  • *Centro di Studio per la Chimica del Farmaco del C.N.R., Istituto di Chimica Farmaceutica dell' Università 'La Sapienza', I-00185 Rome, Italy
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Publikationsdatum:
20. August 2002 (online)

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Horner olefination of aldehydes 1 with N-acyl-2-(diethoxyphosphoryl) glycin ethyl esters 2 to give didehydroamino acid derivatives 3 can be performed advantageously in a 20% aqueous sodium hydroxide/dichloromethane two-phase system in the absence of any typical phase-transfer catalyst.