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Synthesis 1987; 1987(10): 956-958
DOI: 10.1055/s-1987-28265
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Hydrogen Fluoride/Tetrahydrofuran as a Fluorinating Medium. A General Synthesis of 1,1,1,2-Tetrafluoro-2-alkenes

William R. Dolbier, Jr.* , Thomas A. Gray, Keiichi Onnishi
  • *Department of Chemistry, University of Florida, Gainesville, FL, 32611, U.S.A.
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Publication Date:
12 September 2002 (online)

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A general and simple two step synthesis of 1,1,1,2-tetrafluoro-2-alkenes is presented. The key step is the rearrangement-conversion of 1,1,2-trifluoro-1-alken-3-ols under the influence of hydrogen fluoride/tetrahydrofuran (5:1) as a fluorinating medium.

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