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Synthesis 1987; 1987(12): 1121-1122
DOI: 10.1055/s-1987-28193
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Regioselective O-p-Toluenesulfonylation of Nucleosides Under Solid/Liquid Phase-Transfer Conditions

Annie Grouiller* , Hassan Essadiq, Boubker Najib, Patrick Molière
  • *Laboratoire de Chimie biologique, Institut National des Sciences Appliquées de Lyon, Bâtiment 406, F-69621 Villeurbanne, France
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Publikationsdatum:
20. August 2002 (online)

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The regioselective mono-O-p-toluenesulfonylation of nucleosides under phase-transfer conditions in which dibutyltin oxide acts as a base is reported. The selectivity is dependent upon both the solvent and ammonium quaternary salt.