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Synthesis 1987; 1987(9): 829-831
DOI: 10.1055/s-1987-28091
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A Facile Synthesis of 5′-O,6-Cyclo-5,5-dihalogeno-5,6-dihydropyrimidine Nucleosides

Magoichi Sako* , Takao Saito, Keiji Kameyama, Kosaku Hirota, Yoshifumi Maki
  • *Gifu Pharmaceutial University, 6-1, Mitahora-higashi 5 Chome, Gifu 502, Japan
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Publikationsdatum:
12. September 2002 (online)

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Treatment of 2′,3′-O-isopropylidenepyrimidine nucleosides (1; uridine and cytidine) with excess N-halogenosuccinimides in an aprotic solvent at ambient temperature results in the exclusive formation of the corresponding 5′-O,6-cyclo-5, 5-dihalogeno-5,6-dihydro-2′,3′-O-isopropylidenepyrimidine nucleosides 2.