PDF herunterladen
Synthesis 1987; 1987(8): 696-700
DOI: 10.1055/s-1987-28048
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Novel Stereospecific Synthesis of 22-Hydroxylated Triterpenes and Steroids: Syntheses of 22R-Hydroxylanosterol and 22R-Hydroxydesmosterol

Alain Amann* , Guy Ourisson, Bang Luu
  • *Laboratoire de Chimie Organique des Substances Naturelles U A 31, Centre de Neurochimie, 5 rue Blaise Pascal, F-67084 Strasbourg, France
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
12. September 2002 (online)

 als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

22R-Hydroxylanosterol (10) is prepared from lanosterol (1) with an overall yield of over 30%. The key step of the synthesis is the stereospecific coupling of the aldehyde 7 with an arsenic ylide. The same reaction is used to build the side chain of 22R-hydroxydesmosterol (14).