Synthesis 1987; 1987(6): 568-570
DOI: 10.1055/s-1987-28007
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A Convenient Benzylation Procedure for ß-Hydroxy Esters

Ulrich Widmer*
  • *Pharmazeutische Forschungsabteilung, F. Hoffmann-La Roche & Co. AG, CH-4002 Basel, Switzerland
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Publication History

Publication Date:
20 August 2002 (online)

Benzylation of ß-hydroxy esters, containing primary and secondary alcohol functions, with benzyl 2,2,2-trichloroacetimidate gives the corresponding benzyl ethers in good yield. In the case of chiral substrates no racemisation is observed.

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