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Synthesis 1987; 1987(4): 396-397
DOI: 10.1055/s-1987-27960
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Simple N-Alkylation and N-Acylation of 3-Acetylindole and 3-Indolecarbaldehyde

Takushi Kurihara* , Toshiro Fujimoto, Shinya Harusawa, Ryuji Yoneda
  • *Osaka University of Pharmaceutical Sciences, 2-10-65, Kawai, Matsubara, Osaka 580, Japan
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Publikationsdatum:
20. August 2002 (online)

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Using lithium cyanide a simple method for the transformation of 3-acetylindole into the N-alkyl, N-acyl, and N-p-toluenesulfonyl derivatives in good yield is reported. 3-Indolecarbaldehyde is also N-alkylated by the same procedure.