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Synthesis 1987; 1987(3): 298-299
DOI: 10.1055/s-1987-27925
DOI: 10.1055/s-1987-27925
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Eine einfache Synthese von 1-Amino-cyclopropan-1-carbonsäure
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Publikationsdatum:
12. September 2002 (online)
A Simple Synthesis of 1-Aminocyclopropane-1-carboxylic acid Conversion of N-Carbobenzyloxy-L-glutamic acid α-methylester (Z-L-glu(OH)OCH3, 1) into the bromo derivative 2 and subsequent γ-elimination by the use of sodium hydride leads to the fully protected synthon 3 in good yields. Deprotection by sodium hydroxide and hydrogenolysis yields almost quantitively the key substance 5.