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Synthesis 1987; 1987(3): 223-225
DOI: 10.1055/s-1987-27895
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Synthesis of α-Amino Acids by Reaction of t-Butyl N-(t-Butoxycarbonyl)iminoacetate With C-Nucleophiles

Peter Münster* , Wolfgang Steglich
  • *Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Straße 1, D-5300 Bonn 1, West Germany
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Publication Date:
12 September 2002 (online)

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The reaction of t-butyl N-(t-butoxycarbonyl)iminoacetate with Grignard reagents or enamines yields N-(t-butoxycarbonyl)amino acid t-butyl esters which can be easily converted into the free amino acids by treatment with acids.

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