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Synthesis 1986; 1986(12): 1037-1038
DOI: 10.1055/s-1986-31865
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Trichloromethyl Carbonochloridate: A Dehydrating Reagent for the Preparation of Nitriles from Aldoximes

Khuong Mai* , Ghanshyam Patil
  • *Section of Medicinal/Organic Chemistry, American Critical Care Division, American Hospital Supply Corporation, McGaw Park, Illinois 60085, U. S. A.
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Publication Date:
12 September 2002 (online)

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Alkyl, aralkyl, aryl, and heteroaryl aldoximes bearing various functionalities are readily converted to the corresponding nitriles in good yields using trichloromethyl carbonochloridate as dehydrating agent.

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