Synthesis 1986; 1986(12): 1032-1035
DOI: 10.1055/s-1986-31863
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Asymmetric Synthesis of threo-(2S,3R)-2-Amino-3-hydroxypentanedioic Acid 5-Amide (threo-ß-Hydroxy-L-glutamine)

Silvia Cardani* , Laura Prati, Ornella Tinti
  • *Dipartimento di Chimica Organica e Industriale dell'Università, Via Venezian 21, I-20133 Milano, Italy
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Publication History

Publication Date:
12 September 2002 (online)

A new method for the synthesis of threo-ß-hydroxy-L-glutamine consists of epoxidation of (S)-3-benzyloxycarbonyl-5-oxo-4-vinyltetrahydro-1, 3-oxazole (protected L-vinylglycine) and regioselective ring cleavage.

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