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Synthesis 1986; 1986(1): 81-82
DOI: 10.1055/s-1986-31487
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Synthesis of N-t-Butoxycarbonyl-4,4-dideuterio-L-proline

Jean-Robert Dormoy* , Bertrand Castro
  • *Centre CNRS-INSERM de Pharmaco-Endocrinologie, B. P. 5055, F-34033 Montpellier, France
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Publication Date:
20 August 2002 (online)

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The title compound, which is useful for structural investigations of proline-containing peptides by 1H-N.M.R. spectroscopy, has been synthesized in five simple steps from N-t-butoxycarbonyl-4-hydroxyproline and designed for a maximal deuterium incorporation. The deuterium content was nearly 90%.